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KMID : 0361020220650080472
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Korean Journal of Otolaryngology - Head and Neck Surgery
2022 Volume.65 No. 8 p.472 ~ p.475
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Effect of Dexamethasone Combination With Gentamicin in Chemical Labyrinthectomy on Hearing Preservation in Patients With Meniere’s Disease
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Lee Yu-Jin
Lee Jeon-Mi
Lee Hyun-Jin
Na Gi-Na
Kim Sung-Huhn
Bae Seong-Hoon
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Abstract
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Chemical labyrinthectomy may be performed in patients with Meniere’s disease who have intractablevertigo that does not respond to drug. By using aminoglycosides, the surgical procedureablates vestibular type 1 hair cells. However, the risk of hearing loss remains a main concernfor clinicians because gentamicin ablates cochlear hair cells as well as vestibular haircells. To deal with the concern for hearing loss, dexamethasone can be combined with gentamicinduring chemical labyrinthectomy. Herein, we show that chemical labyrinthectomy usinggentamicin combined with dexamethasone preserve hearing at high-frequency compared tothe conventional method.
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KEYWORD
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Dexamethasone, Gentamicin, Meniere disease
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